In this clinic-based study of women with PCOS performed at a large academic center, we found that being high risk for OSA is indeed associated with increased rates of moderate/severe symptoms of depression and anxiety, confirming that what has previously been seen in the general population also extends to this special population. Given the increased prevalence of OSA and psychiatric comorbidities in women with PCOS, the importance of screening and treating these disorders in this population has
previously been acknowledged, but as separate entities.This study brings to light the importance of considering how these comorbidities may be interrelated.
Obesity and insulin resistance, common features of PCOS, are also proposed risk factors for OSA. Obesity, in particular, is one of the strongest predictors for OSA due to associated changes in upper airway anatomy. Obesity and insulin resistance have also
been linked to mental health comorbidities in PCOS.
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