This study showed that treatment of patients with moderate OSA with either MAD or CPAP therapy had no profound effect on major cardiovascular risk factors after 12 months of therapy. While cardiovascular treatment outcome was similar between both therapies, AHI and minimal oxygen saturation differed significantly between groups at follow-up and favored CPAP therapy.
The mean age in this cohort was 50 ± 9.7 years in the MAD group and 51 ± 9.8 years in the CPAP group. This is relatively young compared to other studies of OSA treatment, which mostly reported a mean age around 60 years. This could explain the relatively normal baseline cardiovascular and metabolic values of the study participants, and the fact that no major improvements in the outcomes and cardiovascular risk, such as HR, SBP, and DBP, were seen.
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