The results of our study show that nucleosomes and dsDNA
in serum are increased in patients with OSA in comparison
with participants without OSA. An increase in both cell death
biomarkers was also detected in ACS patients compared with
patients without any cardiovascular event, independently of the
presence of OSA. The present findings suggest that: (1) OSA
may be implicated in the increased levels of the two cell death–
related biomarkers; (2) the extensive cell lysis resulting from
an MI appears to be the major contributor to the high levels
of both biomarkers detected in patients after an ACS; (3) OSA
does not seem to contribute to such elevation when this acute
event occurs.
Figure 1—Workflow diagram depicting timeline and participant recruitment. AHI = apnea-hypopnea index; ACS = acute coronary syndrome;
dsDNA = double-stranded DNA; ISAACC = Impact of Sleep Apnea Syndrome in the Evolution of Acute Coronary Syndrome; OSA = obstructive
sleep apnea syndrome; PG = polygraphy; PSG = polysomnography.
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