his is the first study to show that in patients with HFrEF, the VE/VCO 2 slope is associated with severe OSA. When patients with HF perform exercise, an augmented ventilatory response could alert them to the presence of co-morbid severe OSA, which if
unrecognized could contribute to excess hospital re-admissions and mortality. Notably, an increased VE/VCO2 slope has been shown to be associated with the mortality of patients with HF. We must emphasize that BMI, LVEF, and other parameters of exercise, specifically peak VO 2 were not associated with severe OSA.
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