The present study was a short-term clinical trial where we compared TSD therapy and MAD therapy. The results showed that the efficacy of TSD therapy is comparable to that of MAD therapy in terms of REI and fatigue reduction. However, as compared to patients using MAD, patients using TSD had a lower acceptance rate of the treatment, lower self-reported improvement in daytime sleepiness and QOL, increased BP and a higher self-reported frequency of adverse effects.
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